Preface

Preface

From Annual Report 2019,2020,2021

Following the completion of the first 5 years of the Department of Epilepsy, Movement Disorders and Physiology from August 2013 to May 2018, the next 5 years of this department has started as “the Industry-Academia Collaboration Course” from June 1st, 2018. We are very pleased to make a summary report for the initial 3 years and a half, as similarly done since 2013 previously. Since the middle of this period, the beginning of 2020, the unprecedented COVID-19 pandemic disaster has swept the world and has impeded all aspects of research, clinical practice and education. Nevertheless, we could manage to continue our activity and we would like to express our sincere gratitude for the cooperation of everyone involved in and supporting this department.

First of all, we sincerely appreciate that this department has received support as “the Industry-Academia Collaboration Course” for collaborative research by Eisai Co., Ltd., and for endowment by Nihon Kohden Co., Ltd., Otsuka Pharmaceutical Co., Ltd., and UCB Japan Co., Ltd (as listed by alphabetical order). Within the Kyoto University, we are grateful to e warmest and continuous support by the management committee by Department of Neurology (chaired by Prof. Ryosuke Takahashi), and also by the Departments of Neurosurgery (Prof. Susumu Miyamoto), Psychiatry (Prof. Toshiya Murai), Pediatrics (Prof. Toshio Heike and then Prof. Junko Takita), and Diagnostic Imaging & Nuclear Medicine (Prof. Kaori Togashi and then Prof. Yuji Nakamoto), and as an external member Eisai Co., Ltd.(Mr.Toshihisa Hanada and then Dr. Ryan Edbert Husni) for their guidance.

This course started 1) a five-year contracted collaborative research (with Eisai Co., Ltd.) in the form of an “industry-academia collaborative course”. The content can be summarized as “Clinical research on the characteristics of paroxysmal depolarization shifts (PDS) with a focus on human epilepsy, and the individualization of the action mechanisms of antiepileptic drugs, and generator mechanisms of infraslow, DC shifts and cortical spreading depolarization (CSD) for chronic epilepsy, migraine, and cerebrovascular disorders”, and the details are described separately in this report. The following items ‒ items 2) and 3) ‒ corresponded to the contributed matters done “Department of Epilepsy, Movement Disorders and Physiology” so far. 2) Clinical activity and education: Our objectives include multidisciplinary approaches to elucidate pathophysiology “epilepsy/movement disorders”. promotion of its treatment and highly advanced medicine, and its establishment and dissemination as a practical clinical treatment.
Simultaneously, we seek to provide training and educational opportunities for specialists and clinical researchers who will play a future role in the field ‒ both in Japan and abroad. 3) Research: Our objectives include promoting the development of both clinical neurophysiology research with clinical application and epilepsy research and treatment. It is because both are two sides of the same coin.

In item 1) mentioned above, the novel “clinical research of the characterization of PDS focused on epilepsy and the individualization of the action mechanisms of antiepileptic drugs” have been published in many international journals. PDS focused on human epilepsy are not simply giant pathological EPSP as was conventionally understood, but also it could extensively vary in duration and the degree of involved in which humoral factors or postsynaptic membrane receptors (which act as carriers) .It is understood that important information will be provided by the analyses on the clinical effects of the AMPA receptor antagonists and other drugs that have direct and indirect inhibitory mechanisms on PDS, and increasing the translatability of these results to basic experiments (Please refer to III. Activity report of this report for results of each study).

In item 2) mentioned above, we have directly contributed as much as possible within the university hospital (e.g., elecetrocerebral inactivity and so on) over the past years (since the start of our course in 2013) in the fields of EEG, epilepsy and movement disorders. We have also simultaneously directly continued contributing at the Kyoto/Kinki regional level by organizing annual EEG/EMG seminar (which is held every winter) for physicians and clinical
technologists; and at a national level for annual advanced EEG teaching course (held every summer). We have accepted an average of 3-4 or more EEG/Epilepsy fellows in a year in collaboration with the department neurology in order to provide specialized education for future specialists. We have also trained 3-4 EEG/ epilepsy fellowship supported and granted by The Japanese Society of Neurology since 2017 again in collaboration with the department of neurology.

In item 3) mentioned above, we have promoted domestic and international collaborative research as a member of the planning team for the new academic research of the “oscillology” (Interdisciplinary Area: Non-linear Neurooscillology: Towards Integrative Understanding of Human Nature) , as well as domestic multi-institutional collaborative research and collaborative research with overseas institutions at the Japan Agency for Medical Research and Development (AMED) (research aimed at clarifying glial function in intractable epilepsy pathologies and to prepare medical treatment guidelines).

In this annual report, I would like to analyze the current situation and conduct a self-ssessment by summarizing what we have done in the last 3 and a half years since 2018 from the viewpoint of 3 important axes of clinical practice, education, and research. It could help us improve and modify the current condition, and also start the new concerns. We would greatly appreciate your any feedback to us that is very helpful for our future contribution to the patients in this planet. Finally, this annual report was created with the support of our course members and associates, and I would like to express my gratitude for them here.

February, 2022
With my best wishes,

Preface

From Annual Report 2018

Since two years have past after we have the issued the third annual reports of the Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, it is again my great honor and pleasure that we could issue the fourth annual report. We made it for the last two years because we hosted the 51st Annual Congress of the Japan Epilepsy Society (November 3-5, 2017, Kyoto). We appreciate very much all of you who kindly gave the very important comments and suggestion, upon the previous annual reports from other places and fields.

First of all, since the establishment of this department in August 2013, we have been supported, as the endowed department, by GlaxoSmithKline K.K., Niho Kohden Co., Otsuka Pharmaceutical Co., and UCB Japan Co. Ltd. Within the Kyoto University, we greatly appreciate the warmest and continuous support by the Department of Neurology (chaired by Prof. Ryosuke Takahashi), and also by the Departments of Neurosurgery (Prof. Susumu Miyamoto), Psychiatry (Prof. Toshiya Murai), Pediatrics (Prof. Toshio Heike), and Diagnostic Imaging & Nuclear Medicine (Prof. Kaori Togashi).

Based on or in addition to the daily clinical practice for patients with epilepsy and movement disorders in the Kyoto University Hospital, the aim of this Department was originally planned as follows. 1） Clinical Research: To solve pathophysiology of epilepsy and movement disorders, and to develop new treatments that could lead to the advanced medical care. We also aim at standardizing it in clinical practice. 2） Translatable and Translational Research: To promote clinical practice and research of clinical neurophysiology on epilepsy and movement disorders and its clinical application, because basic- and clinical epileptology and movement disorders are very closely related to neurophysiological knowledge and methods. 3） Education: To provide the integrated teaching opportunity for training of physician-scientists, clinical specialists and leaders of related fields internationally. For instance, since 2011, We started the EEG/Epilepsy fellowship program in cooperation with department of Neurology and we also have provided education course in Japan Neurology Society fellowship program (EEG course) since 2017. 4） Industry-academia collaboration under the appropriate COI management.

Upon the completion of the fifth year, we again greatly appreciate all of the Departments of Kyoto University Graduate School of Medicine and all of the Clinical Divisions of the Kyoto University Hospital for their warmest and sincere support to our activity. Without this supports, we could not complete any of them by all means that were reported in this annual report. It was also strongly supported by so many collaborators, researchers and friends in Japan and also internationally.

In this annual report, we are also very pleased to report the outcome and the current state of industry-academia collaboration. We hope that it may represent a positive face of endowment department in general and that it may help industry partners understand the significance of the endowment department in the future plan.

We again tried to summarize what we could do and not, which help us analyze and understand the situation, and then help us improve and modify the current condition, and also start the new concerns. We would greatly appreciate your any feedback to us that is very helpful for our future contribution to the patients close to or distant from us.

At the end of my preface, I thank all of our friends very much whoever kindly worked hard to make and edit this annual report.

December, 2018

With my best wishes,

ps: Following the completion of endowment departmenrt in May 2018, Department of Epilepsy, Movement Disorders andPhysiology continue as the Industry-Academia Collaboration Course, Kyoto University Graduate School of Medicine.

 

Preface

From Annual Report 2016

Since two years have past after we have the issued the first and second annual reports of the Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, it is again my great honor and pleasure that we could issue the third annual report. We appreciate very much all of you who kindly gave the very important comments and suggestion, upon the previous annual reports from other places and fields.

First of all, since the establishment of this department in August 2013, we have been supported, as the endowed department, by GlaxoSmithKline K.K., Niho Kohden Co., Otsuka Pharmaceutical Co., and UCB Japan Co. Ltd. Within the Kyoto University, we greatly appreciate the warmest and continuous support by the Department of Neurology (chaired by Prof. Ryosuke Takahashi), and also by the Departments of Neurosurgery (Prof. Susumu Miyamoto), Psychiatry (Prof. Toshiya Murai), Pediatrics (Prof. Toshio Heike), and Diagnostic Imaging & Nuclear Medicine (Prof. Kaori Togashi).

Based on or in addition to the daily clinical practice for patients with epilepsy and movement disorders in the Kyoto University Hospital, the aim of this Department was originally planned as follows.
1）Clinical Research: To solve pathophysiology of epilepsy and movement disorders, and to develop new treatments that could lead to the advanced medical care. We also aim at standardizing it in clinical practice.
2）Translatable and Translational Research: To promote clinical practice and research of clinical neurophysiology on epilepsy and movement disorders and its clinical application, because basic- and clinical epileptology and movement disorders are very closely related to neurophysiological knowledge and methods.
3）Education: To provide the integrated teaching opportunity for training of physician-scientists, clinical specialists and leaders of related fields internationally.
4）Industry-academia collaboration under the appropriate COI management

Upon the completion of the third year, we again greatly appreciate all of the Departments of Kyoto University Graduate School of Medicine and all of the Clinical Divisions of the Kyoto University Hospital for their warmest and sincere support to our activity. Without this supports, we could not complete any of them by all means that were reported in this annual report. It was also strongly supported by so many collaborators, researchers and friends in Japan and also internationally.

In this annual report, we are also very pleased to report the outcome and the current state of industry-academia collaboration. We hope that it may represent a positive face of endowment department in general and that it may help industry partners understand the significance of the endowment department in the future plan.

We again tried to summarize what we could do and not, which help us analyze and understand the situation, and then help us improve and modify the current condition, and also start the new concerns. We would greatly appreciate your any feedback to us that is very helpful for our future contribution to the patients close to or distant from us.

At the end of my preface, I thank all of our friends very much whoever kindly worked hard to make and edit this annual report.

August 2016

With my best wishes,

Preface

From Annual Report 2015

Since one year has past after we have issued the first annual report of the Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine in 2014, it is again my great honor and pleasure that we could issue the second annual report. We appreciate very much all of you who kindly gave the very important comments and suggestion, upon the first annual reports from all over the place.
First of all, since the establishment of this department in August 2013, we have been supported, as the endowed department, by GlaxoSmithKline K.K., Niho KohdenCo., Otsuka Pharmaceutical Co., and UCB Japan Co. Ltd. Within the Kyoto University,we greatly appreciate the warmest and continuous support by the Department ofNeurology (chaired by Prof. Ryosuke Takahashi), and also by the Departments ofNeurosurgery (Prof. Susumu Miyamoto), Psychiatry (Prof. Toshiya Murai), Pediatrics (Prof. Toshio Heike), and HumanBrain Research Center (Prof. Hidenao Fukuyama) and Diagnostic Imaging & Nuclear Medicine (Prof. Kaori Togashi).

Based on or in addition to the daily clinical practice for patients with epilepsy and movement disorders in the KyotoUniversity Hospital, the aim of this Department was originally planned as follows.
1) Clinical Research: To solve pathophysiology of epilepsy and movement disorders, and to develop new treatments that could lead to the advanced medical care. We also aim at standardizing it in clinical practice.
2) Translatable and Translational Research: To promote clinical practice and research of clinical neurophysiology on epilepsy and movement disorders and its clinical application, because basic- and clinical epileptology and movement disorders are very closely related to neurophysiological knowledge and methods.
3) Education: To provide the integrated teaching opportunity for training of physician-scientists, clinical specialists and leaders of related fields internationally.

Upon the completion of the second year, we again greatly appreciate all of the Departments of Kyoto University Graduate School of Medicine and all of the Clinical Divisions of the Kyoto University Hospital for their warmest and strong support to our activity. Without their support, we could not complete any of them by all means that were reported in this annual report. It was also strongly supported by so many collaborators, researchers and friends inJapan and also internationally.

We again tried to summarize what we could do and not, which help us analyze and understand the situation, and then help us improve and modify the current condition, and also start the new concerns. We would greatly appreciate your any feedback to us that is very helpful for our future contribution to the patients close to or distant from us.

At the end of my preface, I thank all of our friends very much whoever kindly worked hard to make and edit this annual report.

August 2015

With my best wishes,

Preface

From Annual Report 2014

It is my great honor and pleasure that we could issue the first annual report of the Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine. It was decided to establish in June, 2013, and then I was appointed as the Chairman and the Professor of this Department in August,2013. It is the endowed Department, supported by GlaxoSmithKline K.K., NIHONKOHDEN CORPORATION, Otsuka Pharmaceutical Co., and UCB Japan Co., Ltd. Theactivity of this Department is officially supported by the Department of Neurology(chaired by Prof. Ryosuke Takahashi), and also by the Departments of Neurosurgery(Prof. Susumu Miyamoto), Human Brain Research Center (Prof. Hidenao Fukuyama),Psychiatry (Prof. Toshiya Murai), and Pediatrics (Prof. Toshio Heike).

Based on or in addition to the daily, clinical practice for patients with epilepsy and movement disorders in the KyotoUniversity Hospital, the aim of this Department was planned as follows.

1） To solve pathophysiology of epilepsy and movement disorders, and to develop new treatments that could lead to　the advanced medical care. We also aim at standardizing it in clinical practice.
2） To promote clinical practice and research of clinical neurophysiology on epilepsy and movement disorders and its clinical application, because basic- and clinical epileptology and movement disorders are very closely related to neurophysiological knowledge and methods.
3） To provide the integrated teaching opportunity for training of physcian-scientists, clinical specialists and leaders of related fields internationally.

In the last year we tried to conduct our initial purposes. However, since it was the first year after launching, it wasspent more to prepare to conduct the various listed activities. Fortunately, we could at least partly continue our activity because many of us used to do in the Department of Neurology until its was founded, because we were allowed to continue with the great support by the Department of Neurology (Prof. Takahashi).

Upon the completion of the first year, we greatly appreciate all of the Departments of Kyoto University Graduate School of Medicine and all of the Clinical Divisions of the Kyoto University Hospital for their warmest and sincere support to our activity. Without this support, we could not complete any of them by all means that were reported in this annual report. It was also strongly supported by so many collaborators, researchers and friends in Japan and also internationally.

We tried to summarize what we could do and not, which help us analyze and understand the situation, and then help us improve and modify the current condition, and also start the new concerns. We would greatly appreciate your any feedback to us which is very helpful for our future contribution to the patients in this planet.

At the end of my preface, I thank all of our friends very much whoever kindly worked hard to make and edit this annual report.

August 2014

With my best wishes,

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